Double strand breaks (DSB) in the DNA backbone are the most lethal type of defect induced in the cell nucleus by chemical and radiation treatments of cancer.However, little is known about the outcomes of damage in nucleosomal DNA, and on its effects on damage repair.We performed microsecond-long molecular dynamics computer simulations of Chilling S
Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva.Asymptomatic or unnoticed infections in the lower reproductive tract of women can Footstools lead to serious, long-term consequences if these infections ascend into the fallopian tube.Th
Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable WORMWOOD the catalytic serine residue of acetylcholinesterase (AChE).Because these agents also affect vertebrate AChEs, they are toxic to non-target species including humans and birds.We previously reported that a cyst
Currently, buildings are on the rise, which causes significant environmental pollution due to the lack of controlled landfills to deposit solid construction wast; an alternative solution is to recycle this waste produced by the construction and or demolition of concrete elements structural, and use them as coarse aggregate in the manufacture of con
Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans.This may be due to the visually elusive nature of many malformations on MRI.Here, we utilize a quantitative a